PUBLICATIONS

Research

Calcium polyphosphate publications on materials development, bone repair, and tissue engineering.

Calcium polyphosphate publications

2026
Electrodeposition of Calcium Polyphosphate on Ti-6Al-4V Substrates for Rapid Osseointegration in Orthopedic Applications
Li ZL, Shafiee B, Qu N, Chen R, Xie M, Wei J, Grynpas M, Zou Y.
ACS Applied Bio Materials · 9(13): 5823–5836.
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2020
Differential response of human blood leukocytes to brushite, monetite, and calcium polyphosphate biomaterials
Fine N, Sheikh Z, Al-Jaf F, Oveisi M, Borenstein A, Hu Y, Pilliar R, Grynpas M, Glogauer M.
Journal of Biomedical Materials Research Part B: Applied Biomaterials · 108(1): 253–262.
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2019
Processing and properties of Na-doped porous calcium polyphosphates - Mechanical properties and in vitro degradation characteristics
Pilliar RM, Hu X, Grynpas MD, Kandel RA.
Journal Of The Mechanical Behavior Of Biomedical Materials · 91: 355–365.
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2017
Calcium polyphosphate particulates for bone void filler applications
Pilliar RM, Kandel RA, Grynpas MD, Theodoropoulos J, Hu Y, Allo B, Changoor A.
Journal of Biomedical Materials Research Part B: Applied Biomaterials · 105(4): 874–884.
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2016
Phase transformations during processing and in vitro degradation of porous calcium polyphosphates
Hu Y, Pilliar R, Grynpas M, Kandel R, Werner-Zwanziger U, Filiaggi M.
Journal of Materials Science: Materials in Medicine · 27(7): 117.
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Earlier CPP publications · 2001–2014 (19)

2014
Porous calcium polyphosphate bone substitutes: additive manufacturing versus conventional gravity sinter processing-effect on structure and mechanical properties
Hu Y, Shanjani Y, Toyserkani E, Grynpas M, Wang R, Pilliar R.
Journal of Biomedical Materials Research Part B: Applied Biomaterials · 102(2): 274–283.
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2013
Effect of potassium and magnesium doping on mechanical properties and in vitro degradation behavior of calcium polyphosphate
N. Abbarin; T. W. Coyle; M. D. Grynpas.
Journal of Materials Science · 48(4): 1604–1613.
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2013
Porous calcium polyphosphate as load-bearing bone substitutes: in vivo study
Pilliar RM, Kandel RA, Grynpas MD, Hu Y.
Journal of Biomedical Materials Research Part B: Applied Biomaterials · 101(1): 1–8.
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2013
Solid freeform fabrication of porous calcium polyphosphate structures for bone substitute applications: in vivo studies
Shanjani Y, Hu Y, Toyserkani E, Grynpas M, Kandel RA, Pilliar RM.
Journal of Biomedical Materials Research Part B: Applied Biomaterials · 101(6): 972–980.
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2012
The incorporation of a zone of calcified cartilage improves the interfacial shear strength between in vitro-formed cartilage and the underlying substrate
St-Pierre JP, Gan L, Wang J, Pilliar RM, Grynpas MD, Kandel RA.
Acta Biomaterialia · 8(4): 1603–1615.
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2010
Calcification of cartilage formed in vitro on calcium polyphosphate bone substitutes is regulated by inorganic polyphosphate
St-Pierre JP, Pilliar RM, Grynpas MD, Kandel RA.
Acta Biomaterialia · 6(8): 3302–3309.
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2008
Polymeric crystallization and condensation of calcium polyphosphate glass
Sidney Omelon; Andrew Baer; Tom Coyle; Robert M. Pilliar; Rita Kandel; Marc Grynpas.
Materials Research Bulletin · 43(1): 68–80.
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2007
Formation of biphasic constructs containing cartilage with a calcified zone interface
Allan KS, Pilliar RM, Wang J, Grynpas MD, Kandel RA.
Tissue Engineering · 13(1): 167–177.
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2007
Osteochondral defect repair using a novel tissue engineering approach: sheep model study
Pilliar RM, Kandel RA, Grynpas MD, Zalzal P, Hurtig M.
Technology and Health Care · 15(1): 47–56.
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2007
The Effect of Sodium Dopants on Calcium Polyphosphate Biomaterials
Judy Ue; R.M. Pilliar; R.A. Kandel; Tom W. Coyle; M.D. Grynpas.
Key Engineering Materials · 361-363: 281–284.
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2006
Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model
Kandel RA, Grynpas M, Pilliar R, Lee J, Wang J, Waldman S, Zalzal P, Hurtig M, CIHR-Bioengineering of Skeletal Tissues Team.
Biomaterials · 27(22): 4120–4131.
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2004
Long-term intermittent compressive stimulation improves the composition and mechanical properties of tissue-engineered cartilage
Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Kandel RA.
Tissue Engineering · 10(9-10): 1323–1331.
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2004
Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrate
Séguin CA, Grynpas MD, Pilliar RM, Waldman SD, Kandel RA.
Spine · 29(12): 1299–306; discussion 1306–7.
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2003
Chondrocyte interactions with porous titanium alloy and calcium polyphosphate substrates
Ciolfi VJ, Pilliar R, McCulloch C, Wang SX, Grynpas MD, Kandel RA.
Biomaterials · 24(26): 4761–4770.
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2003
Long-term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro
Waldman SD, Spiteri CG, Grynpas MD, Pilliar RM, Kandel RA.
Journal of Orthopaedic Research · 21(4): 590–596.
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2002
Characterization of cartilagenous tissue formed on calcium polyphosphate substrates in vitro
Waldman SD, Grynpas MD, Pilliar RM, Kandel RA.
Journal Of Biomedical Materials Research · 62(3): 323–330.
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2002
Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies
Grynpas MD, Pilliar RM, Kandel RA, Renlund R, Filiaggi M, Dumitriu M.
Biomaterials · 23(9): 2063–2070.
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2001
Fabrication of porous calcium polyphosphate implants by solid freeform fabrication: a study of processing parameters and in vitro degradation characteristics
Porter NL, Pilliar RM, Grynpas MD.
Journal Of Biomedical Materials Research · 56(4): 504–515.
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2001
Porous calcium polyphosphate scaffolds for bone substitute applications -- in vitro characterization
Pilliar RM, Filiaggi MJ, Wells JD, Grynpas MD, Kandel RA.
Biomaterials · 22(9): 963–972.
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Related polyphosphate chemistry and biomineralization (6)

2016
Book chapter
Inorganic Polyphosphate in Tissue Engineering
Rahul Gawri; Jean-Philippe St-Pierre; Robert Pilliar; Marc Grynpas; Rita A. Kandel.
Inorganic Polyphosphates in Eukaryotic Cells: 217–239.
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2013
A review of phosphate mineral nucleation in biology and geobiology
Omelon S, Ariganello M, Bonucci E, Grynpas M, Nanci A.
Calcified Tissue International · 93(4): 382–396.
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2011
Polyphosphates affect biological apatite nucleation
Omelon S, Grynpas M.
Cells, Tissues, Organs · 194(2-4): 171–175.
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2009
Control of vertebrate skeletal mineralization by polyphosphates
Omelon S, Georgiou J, Henneman ZJ, Wise LM, Sukhu B, Hunt T, Wynnyckyj C, Holmyard D, Bielecki R, Grynpas MD.
PLOS ONE · 4(5): e5634.
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2008
Relationships between polyphosphate chemistry, biochemistry and apatite biomineralization
Omelon SJ, Grynpas MD.
Chemical Reviews · 108(11): 4694–4715.
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2007
A nonradioactive method for detecting phosphates and polyphosphates separated by PAGE
Omelon S, Grynpas M.
Electrophoresis · 28(16): 2808–2811.
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Published conference abstract

2016
Conference abstract
Sodium-doped porous calcium polyphosphate – strength and in vitro degradation characteristics
Youxin Hu; Corey Sermer; Rita Kandel; Marc Grynpas; Robert Pilliar.
Frontiers in Bioengineering and Biotechnology · 4.
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Research

Calcium polyphosphate publications

Electrodeposition of Calcium Polyphosphate on Ti-6Al-4V Substrates for Rapid Osseointegration in Orthopedic Applications

Differential response of human blood leukocytes to brushite, monetite, and calcium polyphosphate biomaterials

Processing and properties of Na-doped porous calcium polyphosphates - Mechanical properties and in vitro degradation characteristics

Calcium polyphosphate particulates for bone void filler applications

Phase transformations during processing and in vitro degradation of porous calcium polyphosphates

Porous calcium polyphosphate bone substitutes: additive manufacturing versus conventional gravity sinter processing-effect on structure and mechanical properties

Effect of potassium and magnesium doping on mechanical properties and in vitro degradation behavior of calcium polyphosphate

Porous calcium polyphosphate as load-bearing bone substitutes: in vivo study

Solid freeform fabrication of porous calcium polyphosphate structures for bone substitute applications: in vivo studies

The incorporation of a zone of calcified cartilage improves the interfacial shear strength between in vitro-formed cartilage and the underlying substrate

Calcification of cartilage formed in vitro on calcium polyphosphate bone substitutes is regulated by inorganic polyphosphate

Polymeric crystallization and condensation of calcium polyphosphate glass

Formation of biphasic constructs containing cartilage with a calcified zone interface

Osteochondral defect repair using a novel tissue engineering approach: sheep model study

The Effect of Sodium Dopants on Calcium Polyphosphate Biomaterials

Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model

Long-term intermittent compressive stimulation improves the composition and mechanical properties of tissue-engineered cartilage

Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrate

Chondrocyte interactions with porous titanium alloy and calcium polyphosphate substrates

Long-term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro

Characterization of cartilagenous tissue formed on calcium polyphosphate substrates in vitro

Porous calcium polyphosphate scaffolds for bone substitute applications in vivo studies

Fabrication of porous calcium polyphosphate implants by solid freeform fabrication: a study of processing parameters and in vitro degradation characteristics

Porous calcium polyphosphate scaffolds for bone substitute applications -- in vitro characterization

Inorganic Polyphosphate in Tissue Engineering

A review of phosphate mineral nucleation in biology and geobiology

Polyphosphates affect biological apatite nucleation

Control of vertebrate skeletal mineralization by polyphosphates

Relationships between polyphosphate chemistry, biochemistry and apatite biomineralization

A nonradioactive method for detecting phosphates and polyphosphates separated by PAGE

Sodium-doped porous calcium polyphosphate – strength and in vitro degradation characteristics